OAB-NC occurs when there is interference in the signals between your brain and bladder because of a neurologic condition. This causes the bladder muscle to become overactive, which can lead to leakage.

OAB-NC is not a "weak" bladder. It occurs when nerves are affected due to a neurologic condition. These nerves send signals to your bladder at the wrong time, causing the muscle to squeeze without warning. This process causes your bladder muscle to contract uncontrollably, creating leakage, a strong need to go right away, and a need to go often.

Yes, BOTOX^® is approved to treat leakage of urine (incontinence) in adults with OAB-NC who still have leakage or cannot tolerate the side effects of OAB medication.* BOTOX^® was proven to significantly reduce weekly leakage episodes.^†

*Anticholinergic.

^†At week 6 in clinical trials.

In clinical trials, patients taking BOTOX^® experienced fewer weekly leakage episodes compared to placebo in as little as 2 weeks, with full results seen at week 6.*

*In clinical trials, 6 weeks after treatment, people treated with BOTOX^® had an average of ≈20 fewer leakage episodes per week (or ≈2.8 per day) compared to 11 fewer leakage episodes per week (or ≈1.5 per day) with placebo. In clinical studies, results were measured at 2, 6, and 12 weeks, with 6 weeks being the primary time point.

OAB-NC is a chronic condition that requires ongoing treatment. Your doctor will determine how often you need to get retreated. After your first treatment, you should schedule your next treatment evaluation at about 6 months before you leave the office because it may take some time to get on your doctor's calendar. In clinical studies, adult OAB-NC patients were retreated 42-48 weeks after their initial treatment. If your OAB symptoms return before 6 months, talk to your doctor. A minimum of 12 weeks is needed between treatments.

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The most common adverse reactions (≥ 5% and > placebo) are urinary tract infection and temporary inability to fully empty your bladder.

Nearly all patients could still urinate when they needed to after BOTOX^® treatment; however, there have been instances where some people temporarily could not fully empty their bladder when they urinated. If you have difficulty fully emptying your bladder after receiving BOTOX^®, you may need to use disposable self-catheters. A self-catheter is not like the kind you see in a hospital. It is much smaller (fits in your purse or pocket), easy to use, and you use it by yourself.

You should not receive BOTOX^® if you currently have a urinary tract infection (UTI) or are not willing (or able) to use a disposable self-catheter if necessary.

This list is not a complete list of possible serious side effects. Please see Important Safety Information Including Boxed Warning. Talk to an OAB Specialist familiar with BOTOX^® if you have any concerns.

Your doctor will prescribe you antibiotics to help prevent a urinary tract infection. You will be instructed to take them before, on, and after the day of treatment.

If you are not happy with the results after 12 weeks, talk to your doctor. It's important that you and your doctor are on the same page regarding what you can expect from BOTOX^® treatment. BOTOX^® is not a cure. The effects of BOTOX^® treatment are not permanent.

Most major insurance plans, including Medicare and Medicaid, cover the cost of BOTOX^® treatments.* For commercially insured patients who are eligible, AbbVie offers a savings program to help offset remaining out-of-pocket costs.^†

Learn more and find out if you’re eligible for savings.

*Based on November 2022 Managed Markets Insight & Technology data.

^†Restrictions apply. Please see full eligibility rules for more details.

The BOTOX^® Savings Program and insurance coverage can reduce your treatment costs. In fact, eligible participants may pay as little as $0.

By participating in the BOTOX^® Savings Program, you acknowledge and agree to the full Terms and Conditions set out at BOTOXSavingsProgram.com/TermsandConditions. Patients enrolled in Medicare, Medicaid, TRICARE, or any other government-reimbursed healthcare program are not eligible. Other restrictions and maximum limits apply.